Cysteine-rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis
Identifieur interne : 000914 ( Main/Exploration ); précédent : 000913; suivant : 000915Cysteine-rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis
Auteurs : Yong Fan ; Xinlei Yang ; Juan Zhao ; Xiaoying Sun ; Wenhui Xie ; Yanrong Huang ; Guangtao Li ; Yanjie Hao ; Zhuoli ZhangSource :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2019.
Abstract
Numerous preclinical studies have revealed a critical role of cysteine-rich 61 (Cyr61) in the pathogenesis of rheumatoid arthritis (RA). But there is little literature discussing the clinical value of circulation Cyr61 in RA patients. The aim of our study is to investigate the serum Cyr61 level and its association with disease activity in RA patients.
A training cohort was derived from consecutive RA patients who visited our clinic from Jun 2014 to Nov 2018. Serum samples were obtained at the enrollment time. To further confirm discovery, an independent validation cohort was set up based on a registered clinical trial. Paired serum samples of active RA patients were respectively collected at baseline and 12 weeks after uniformed treatment. Serum Cyr61 concentration was detected by enzyme-linked immunosorbent assay. The comparison of Cyr61 between RA patients and controls, the correlation between Cyr61 levels with disease activity, and the change of Cyr61 after treatment were analyzed by appropriate statistical analyses.
A total of 177 definite RA patients and 50 age- and gender-matched healthy controls were enrolled in the training cohort. Significantly elevated serum Cyr61 concentration was found in RA patients, demonstrating excellent diagnostic ability to discriminate RA from healthy controls (area under the curve (AUC) = 0.98,
Serum Cyr61 levels were remarkably increased in RA patients compared with those in healthy controls. The Cyr61 concentration was inversely correlated with RA disease activity and upregulated in those therapeutic responders.
Combination Therapy Prevents the Relapse of RA,
The online version of this article (10.1186/s13075-019-1906-y) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13075-019-1906-y
PubMed: 31113467
PubMed Central: 6528265
Affiliations:
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Xie</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Huang, Yanrong" sort="Huang, Yanrong" uniqKey="Huang Y" first="Yanrong" last="Huang">Yanrong Huang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Guangtao" sort="Li, Guangtao" uniqKey="Li G" first="Guangtao" last="Li">Guangtao Li</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Hao, Yanjie" sort="Hao, Yanjie" uniqKey="Hao Y" first="Yanjie" last="Hao">Yanjie Hao</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Zhuoli" sort="Zhang, Zhuoli" uniqKey="Zhang Z" first="Zhuoli" last="Zhang">Zhuoli Zhang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31113467</idno><idno type="pmc">6528265</idno><idno 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type="wicri:Area/Main/Exploration">000914</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cysteine-rich 61 (Cyr61): a biomarker reflecting disease activity in rheumatoid arthritis</title><author><name sortKey="Fan, Yong" sort="Fan, Yong" uniqKey="Fan Y" first="Yong" last="Fan">Yong Fan</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Yang, Xinlei" sort="Yang, Xinlei" uniqKey="Yang X" first="Xinlei" last="Yang">Xinlei Yang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhao, Juan" sort="Zhao, Juan" uniqKey="Zhao J" first="Juan" last="Zhao">Juan Zhao</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Sun, Xiaoying" sort="Sun, Xiaoying" uniqKey="Sun X" first="Xiaoying" last="Sun">Xiaoying Sun</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Xie, Wenhui" sort="Xie, Wenhui" uniqKey="Xie W" first="Wenhui" last="Xie">Wenhui Xie</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Huang, Yanrong" sort="Huang, Yanrong" uniqKey="Huang Y" first="Yanrong" last="Huang">Yanrong Huang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Li, Guangtao" sort="Li, Guangtao" uniqKey="Li G" first="Guangtao" last="Li">Guangtao Li</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Hao, Yanjie" sort="Hao, Yanjie" uniqKey="Hao Y" first="Yanjie" last="Hao">Yanjie Hao</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author><author><name sortKey="Zhang, Zhuoli" sort="Zhang, Zhuoli" uniqKey="Zhang Z" first="Zhuoli" last="Zhang">Zhuoli Zhang</name><affiliation><nlm:aff id="Aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">Numerous preclinical studies have revealed a critical role of cysteine-rich 61 (Cyr61) in the pathogenesis of rheumatoid arthritis (RA). But there is little literature discussing the clinical value of circulation Cyr61 in RA patients. The aim of our study is to investigate the serum Cyr61 level and its association with disease activity in RA patients.</p></sec><sec><title>Methods</title><p id="Par2">A training cohort was derived from consecutive RA patients who visited our clinic from Jun 2014 to Nov 2018. Serum samples were obtained at the enrollment time. To further confirm discovery, an independent validation cohort was set up based on a registered clinical trial. Paired serum samples of active RA patients were respectively collected at baseline and 12 weeks after uniformed treatment. Serum Cyr61 concentration was detected by enzyme-linked immunosorbent assay. The comparison of Cyr61 between RA patients and controls, the correlation between Cyr61 levels with disease activity, and the change of Cyr61 after treatment were analyzed by appropriate statistical analyses.</p></sec><sec><title>Results</title><p id="Par3">A total of 177 definite RA patients and 50 age- and gender-matched healthy controls were enrolled in the training cohort. Significantly elevated serum Cyr61 concentration was found in RA patients, demonstrating excellent diagnostic ability to discriminate RA from healthy controls (area under the curve (AUC) = 0.98, <italic>P</italic> < 0.001). In addition, the Cyr61 level in active RA patients was significantly lower than that in patients in remission/low disease activity, and it was inversely correlated with composite disease activity scores and almost all of the components in statistic. Further study in the validation cohort (<italic>n</italic> = 77) showed a significant increase of the Cyr61 level at 12 weeks in ACR responders (ACR20/50/70), while no significant change of the Cyr61 level from baseline was observed in non-responders.</p></sec><sec><title>Conclusions</title><p id="Par4">Serum Cyr61 levels were remarkably increased in RA patients compared with those in healthy controls. The Cyr61 concentration was inversely correlated with RA disease activity and upregulated in those therapeutic responders.</p></sec><sec><title>Trial registration</title><p id="Par5">Combination Therapy Prevents the Relapse of RA, <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT02320630">NCT02320630</ext-link>. Registered 19 December 2014,</p></sec><sec><title>Electronic supplementary material</title><p>The online version of this article (10.1186/s13075-019-1906-y) contains supplementary material, which is available to authorized users.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Smolen, Js" uniqKey="Smolen J">JS Smolen</name></author><author><name sortKey="Aletaha, D" uniqKey="Aletaha D">D Aletaha</name></author><author><name sortKey="Mcinnes, Ib" uniqKey="Mcinnes I">IB McInnes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Burmester, Gr" uniqKey="Burmester G">GR Burmester</name></author><author><name sortKey="Pope, Je" uniqKey="Pope J">JE Pope</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Lf" uniqKey="Lau L">LF Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haas, Cs" uniqKey="Haas C">CS 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H" uniqKey="Pringle H">H Pringle</name></author><author><name sortKey="Kumar, R" uniqKey="Kumar R">R Kumar</name></author><author><name sortKey="West, K" uniqKey="West K">K West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mori, A" uniqKey="Mori A">A Mori</name></author><author><name sortKey="Desmond, Jc" uniqKey="Desmond J">JC Desmond</name></author><author><name sortKey="Komatsu, N" uniqKey="Komatsu N">N Komatsu</name></author><author><name sortKey="O Kelly, J" uniqKey="O Kelly J">J O'Kelly</name></author><author><name sortKey="Miller, Cw" uniqKey="Miller C">CW Miller</name></author><author><name sortKey="Legaspi, R" uniqKey="Legaspi R">R Legaspi</name></author><author><name sortKey="Marchevsky, Am" uniqKey="Marchevsky A">AM Marchevsky</name></author><author><name sortKey="Mckenna, Rj" uniqKey="Mckenna R">RJ McKenna</name></author><author><name sortKey="Koeffler, Hp" uniqKey="Koeffler H">HP 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Huang</name><name sortKey="Li, Guangtao" sort="Li, Guangtao" uniqKey="Li G" first="Guangtao" last="Li">Guangtao Li</name><name sortKey="Sun, Xiaoying" sort="Sun, Xiaoying" uniqKey="Sun X" first="Xiaoying" last="Sun">Xiaoying Sun</name><name sortKey="Xie, Wenhui" sort="Xie, Wenhui" uniqKey="Xie W" first="Wenhui" last="Xie">Wenhui Xie</name><name sortKey="Yang, Xinlei" sort="Yang, Xinlei" uniqKey="Yang X" first="Xinlei" last="Yang">Xinlei Yang</name><name sortKey="Zhang, Zhuoli" sort="Zhang, Zhuoli" uniqKey="Zhang Z" first="Zhuoli" last="Zhang">Zhuoli Zhang</name><name sortKey="Zhao, Juan" sort="Zhao, Juan" uniqKey="Zhao J" first="Juan" last="Zhao">Juan Zhao</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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